Seahawks' Chris Carson suffers significant ankle injury

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The Indianapolis Colts (1-2), led by quarterback Jacoby Brissett, meet the Seattle Seahawks (1-2), led by quarterback Russell Wilson, in an AFC matchup in NFL Week 4 action at CenturyLink Field in Seattle, Washington, on Sunday, October 1, 2017 (10/1/17). The Colts had only 32 yards and three first downs in the second half after leading 15-10 at the break.

Wilson connected on 21 of 26 passes for 295 yards and two touchdowns with two interceptions while the Colts' Brissett threw for 157 yards with one touchdown and one interception. The other INT fell to rookie DB Malik Hooker as the Seahawks were looking to build on an 18-15 lead late in the third quarter.

McKissic added one more touchdown on a nifty 27-yard catch in the end zone for Seattle's final score in what was the most points for Seattle since a 50-17 win at Buffalo in December, 2012.

Andrew Luck told NBC Sports sideline reporter Michelle Tafoya that he's optimistic he will return to practice this week.

While Brissett was critical of his performance, it was the Colts inability to get off the field defensively was just as important.

Carson, the seventh-round pick and Seattle's surprising leading rusher so far this season, got what Carroll termed a "significant" ankle injury when the Colts' Jon Bostic landed on it making a tackle on a run for no gain in the second half. "It's not just from me". We have so many guys who can step up.

"I'm getting sick of not finishing", said safety Darius Butler.

Indianapolis did almost everything right in the first half.

Seattle owned the rest of the game, overwhelming the Colts 36-3 while amassing 337 yards to 24 for Indy in the second half. Seattle has allowed three offensive touchdowns of 30 or more yards in three games, including two last week to Tennessee.

The second touchdown came on an 18-yard fade route by wide receiver Donte Moncrief.

Key Stat: In the game's pivotal third quarter, the Colts had 11 plays for 11 total yards.

Seattle Seahawks running back Chris Carson left Sunday's game with a lower leg injury, and there is reportedly a good chance he could be out for the remainder of the season. Wilson was 13 of 17 passing for 182 yards and two touchdowns in the second half, along with his TD sprint. Seattle lost two defensive starters in cornerback Jeremy Lane (groin) and defensive end Cliff Avril (neck).

"All of his signs are really stable", Carroll said when asked about Odhiambo.

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