The North Londoners were much less impressive during Tuesday's Champions League victory over APOEL - despite the 3-0 scoreline - but the performance highlighted the club's reliance on Harry Kane, who netted his first flawless hat-trick in a Spurs shirt.
Sissoko, a 75th-minute substitute for Eriksen, sidefooted home his first goal for Spurs in time added on - via a deflection off Christopher Schindler - following Davies' cross.
In 16th minute of the game, Ben Davies doubled the lead for his side with a well taken shot. We played Champions League in Cyprus, arrived back home late and then to show the energy and performance is fantastic for us.
City dominated much of the game and were rewarded when De Bruyne found the back of the net in the 67th minute with a fine hit past Thibaut Courtois from the edge of the area.
Six games into the EPL season and not many would have predicted these two sides only being separated by four places and just two points with Huddersfield sitting in eighth position and Tottenham occupying fourth on the EPL table.
Kane is now on 84 Premier League goals - as many as Cristiano Ronaldo scored during his time at Manchester United - and he was given a standing ovation by the whole stadium as he went off in the second-half.
Pochettino made three changes from the team which started the 3-0 win at APOEL Nicosia on Tuesday night.
Who else? Tottenham's superstar and a match-winner to rival any of the Premier League's collected talent.
Kane grabbed his second of the match in the 24th minute with a left-footed strike from 20 yards that ended up in the top-left corner.
Kane opened the scoring following a mistake in the home side's ranks after 10 minutes, coolly slotting his finish in at the near post past the helpless Jonas Lossl.
Dier and Christian Eriksen continued to harass Huddersfield but their impact was limited and Kane failed to see enough of the ball to cause further trouble.
Kane then volleyed narrowly over the crossbar from long range and was almost presented with a gift after Lossl scuffed a clearance straight to him, but the Huddersfield goalkeeper recovered to deny him.
Alli's booking was a minor note in Spurs' victory.
Before this match, Town had only conceded three goals and they can't take heart from the fact they'll meet few better or more confident sides than Tottenham today.
The Colombian worldwide did step up in the second half though and played his part in a domiant defensive display as a team from Tottenham.
Kane, the Premier League's Golden Boot victor for the last two seasons, failed to score in August, but followed up his midweek Champions League hat-trick against Apoel in brilliant fashion.