The Jamaican sprinter, an eight-time Olympic gold medallist with 11 world golds to his name and world record holder in the 100 and 200m, will race just the 100m and 4x100m relay in the British capital.
De Grasse's absence from the 100m unquestionably boosts Bolt's chances of adding an eighth individual world championships gold to his incredible tally in his final solo race on Saturday.
And Bolt, who holds the world records in the 100m and 200m, insisted dopers are endangering the future of athletics.
He ran a time of 9.69 seconds to win in Stockholm, although it was heavily wind assisted, and was heavily tipped by many as the man to push Bolt in the 100m when the championships get under way tomorrow.
"Wayde van Niekerk is proving he is a world star ... for me, he's proving that he can step up to the plate", Bolt said this week. From lane 8, the worst place on the track, van Niekerk took on the field and not only won gold but in running 43.03s the 25-year-old broke Michael Johnson's world record.
"One of the things that we have to start looking towards is having persons with certain skill sets around us".
Bolt was insulted when de Grasse said Bolt was slowing.
The manner in which he charged away from La Shawn Merritt and Kirani James in the home straight in the Olympic 400m final in Rio a year ago was as breathtaking as Bolt at his stunning best in the shorter distances.
"But at the same time, I wish I could have left it and focused on the 100m and the 200m, but I didn't think I would, just because of the fact that I am doing so great in the event".
American sprinter Christian Coleman admits spoiling Usain Bolt's farewell party at the World Championships would be "crazy". You guys know if I show up for a race that means I'm 100 per cent confident.
"It's cool I'm making my debut in Usain's final event", he said.
Remember the man from Canada, who pushed Usain Bolt hard in the semi-final of 200m at Rio Olympics past year? Aside from Jones, you have to go back at least 30 years.
The special video message on Twitter was a sweet gesture by the Indian captain, who also took the opportunity to endorse Puma in the same post.
He explained how his motivation to keep putting his body through such a punishing regime was renewed each year by resetting his goals - with one often created for him by a casually "disrespectful" remark from one of his opponents. Bolt, who turns 31 later this month, looked moved by the images, saying: "It's just brilliant that people in other disciplines respect what you do as they know the work you have to do".
"You can't be happy about doping at all, it's not good for the sport".
"For me, I will go with Zlatan", he said when asked whether himself or the veteran should be signed.